Associate Director, Clinical Pharmacology
Location: South San Francisco
Posted on: June 23, 2025
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Job Description:
The Position: At Maze Therapeutics, we harness the power of
genetics to drive novel target discovery for common diseases,
particularly in renal and cardiometabolic indications. If you're
passionate about drug development and scientific problem-solving in
a collaborative and innovative environment, we invite you to
explore this opportunity. As a key clinical pharmacology expert,
you will thrive in a fast-paced, cross-functional setting,
contributing to the design and execution of clinical pharmacology
and proof-of-concept patient trials. You’ll also lead hands-on data
analysis and help define the Clinical Pharmacology strategy as part
of the broader Clinical Development plan. Reporting directly to the
Head of Clinical Pharmacology, this role offers high visibility and
a significant opportunity to make an impact. The Impact You’ll Have
Lead Clinical Pharmacology Studies : Design and execute studies
supporting the overall Clinical Pharmacology strategy, including
FIH, DDI, rBA/BE, ADME, TQT and special population studies. Drive
Translational Science : Collaborate with internal teams (e.g.
In-vivo/In-vitro Pharmacology, DMPK, and Biology) to develop
translational PK/PD models. Analyze & Interpret Data : Conduct
pharmacokinetic (PK) and pharmacodynamic (PD) data analyses,
including noncompartmental and compartment approaches, data
visualization and summary reports. Regulatory Contributions :
Co-author and review key regulatory documents (IND/CTAs, clinical
protocols, study reports, population PK reports, , investigator
brochures, and other filings). Stay at the Forefront : Keep up with
emerging clinical pharmacology trends, quantitative methods, and
regulatory best practices to enhance Maze’s development programs.
Scientific Communication : Support the preparation of presentations
and manuscripts and attend scientific conferences. As an Associate
Director, we also expect you to demonstrate the following
Leadership Competencies: Communication and Influence Builds
communication channels across Maze for sharing information
Influences Senior Management decisions through persuasive arguments
Respectfully addresses differing opinions leading to support of
decision Teamwork and Collaboration Champions partnerships and
connections across Maze Proactively addresses issues that could
result in breakdown of team relationships Spotlights team and
individual contributions in public forums Execution and Results
Addresses gaps and leverages strengths to get best results
Maintains a steadying presence and clarifies priorities during
change Anticipates and removes barriers that put
functional/corporate goals at risk Develop Others and Self Removes
barriers to staff development and empowers them to make their own
decisions Stays current on industry trends and keeps direct-reports
prepared and responsive What We’re Looking For PhD in Pharmacology
and/or PharmD with at least of 3 years of industry experience in
clinical pharmacology or pharmacometrics, preferably with small
molecules. Experience in renal disease drug development is a plus.
Strong track record in clinical trial design, pharmacology data
analysis, and regulatory submissions (INDs, NDAs, MAAs). Hand-on
experience in pharmacometrics or Quantitative Pharmacology is a
plus. Thorough understanding of global regulatory guidelines
related to clinical pharmacology including modeling best practices,
drug/food interactions, and pediatric drug development regulations
(PREA/BPCA and European Commission guidelines). Proven ability to
manage external vendors effectively. Exceptional organizational,
analytical, and communication skills, ensuring high-quality, timely
data delivery. A curious, adaptable, and collaborative mindset,
with the ability to work independently and cross-functionally.
Ability to travel as needed for conferences, site visits, and
regulatory meetings. About Maze Therapeutics Maze Therapeutics is a
clinical-stage biopharmaceutical company harnessing the power of
human genetics to develop novel, small molecule precision medicines
for patients living with renal, cardiovascular and related
metabolic diseases, including obesity. The company is advancing a
pipeline using its Compass platform, which allows it to identify
and characterize genetic variants in disease and then link those
variants to the biological pathways that drive disease in specific
patient groups through a process it refers to as variant
functionalization. The company’s pipeline is led by two wholly
owned lead programs, MZE829 and MZE782, each of which represents a
novel precision medicine-based approach for chronic kidney disease.
Maze is based in South San Francisco. Our People Maze is comprised
of a team of passionate and creative professionals committed to
discovering and delivering transformative medicines to patients
suffering from both rare and common genetic diseases. We are
fostering a culture that encourages vision, initiative and the
development of talent. Our supportive work environment inspires
creative thinking and freedom of expression, resulting in a
stimulating atmosphere where people enjoy coming to work. While we
have a passion for advanced science and pride ourselves on
excellence in execution, ultimately, everything we do is about
patients. Our Core Values Further Together – Our path is paved with
challenges, but with resilience and a team-first mentality, we’ll
achieve our mission. Impact Obsessed – We embrace the bold, take
calculated risks, and learn from our mistakes to improve the lives
of others. Stand True – Our integrity is foundational; it guides us
no matter the obstacle. The expected annual salary range for
employees located in the San Francisco Bay Area is $203,000 to
$248,000. Additionally, this position is eligible for an annual
performance bonus. Maze performs position-based compensation
benchmarking to industry market data to ensure we pay competitive
wages. Determination of starting salary will depend upon a variety
of job-related factors, which may include professional experience,
skills, and job location. The expected salary range for this role
may be modified in the future. Maze offers a robust benefits
package to our eligible employees including competitive medical,
dental, and vision insurance, mental health offerings, equity
incentive plan, 401(k) program with employer match and a generous
holiday and PTO policy.
Keywords: , San Bruno , Associate Director, Clinical Pharmacology, Science, Research & Development , South San Francisco, California
