Director, Channel Operations

Location: South San Francisco
Posted on: June 23, 2025

Job Description:

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients. Key Accountabilities/Core Job Responsibilities: Distribution Management: Build and maintain strong partnerships with 3PLs, specialty distributors, specialty pharmacies, and customers. Oversee the performance of distribution partners to ensure efficient and compliant operations including quarterly business reviews (QBRs). Develop strategies to support medicine launches, ensure supply continuity, and address distribution challenges. Data Flow, SAP integration & Reporting: Serve as the Denali commercial representative on its SAP implementation team. Lead the integration and optimization of channel operations workflows within the SAP ERP system, ensuring alignment with commercial, accounting, and gross-to-net processes. Manage inventory, sales, and chargeback data flows to ensure timely and accurate information sharing across stakeholders and systems. Collaborate with and manage outsourced vendors to ensure high-quality data integration, aggregation, analytics, and reporting services. Provide data-driven insights to inform decision-making and support market access strategies. Contract Administration: Administer any contract related payments with 3PLs, specialty distributors, specialty pharmacies and customers. Ensure accuracy and classification of contract-related payments for partners and help ensure data structures and data flows provide for government price reporting accuracy and compliance. Ensure documentation and secure database for all contract related contracts, SOP’s, and payments and that customers receive accurate contract pricing. Operational Oversight: Monitor performance metrics and contractual compliance for distribution partners and outsourced vendors. Drive continuous improvement initiatives to optimize the distribution model, contract administration process and enhance efficiencies. Ensure adherence to regulatory requirements and industry standards. Cross-Functional Collaboration: Partner with internal teams, including supply chain, government price reporting lead, commercial, regulatory, and finance, to align distribution activities with organizational goals and help ensure compliance. Serve as a key point of contact for resolving distribution-related issues and fostering teamwork across functions. Contribute as appropriate with technical operations and the supply chain team on all topics that may impact product packaging. Act as a key contact for external auditors, responding to inquiries and data requests, and assisting in resolution of discrepancies. Prepare and maintain audit-ready documentation to support SOX compliance and other regulatory requirements. Qualifications Bachelor’s degree in business, supply chain, or related field (MBA or advanced degree preferred). 7 years of experience in channel operations, distribution, and supply chain within the biopharma or healthcare industry. Experience managing relationships with 3PLs, specialty distributors, and specialty pharmacies. Strong knowledge of data management, including inventory, sales, and chargeback processes. Experience with administering distribution and customer related contracts. Experience with ERP systems including SAP Familiarity with rare disease markets and the unique challenges of patients with rare diseases. Exceptional project management, analytical, and problem-solving skills. Excellent communication and interpersonal skills with a collaborative mindset. Critical Success Factors Flexibility and Agility: Ability to thrive in a fast-paced, efficient environment and manage competing priorities. Strategic and Tactical Balance: Capable of shaping long-term strategies while executing operational details effectively. Team Player: Willingness to collaborate across functions and contribute to a positive, solution-oriented culture. Proactive Mindset: Anticipates challenges, seeks innovative solutions, and takes initiative to improve processes. This is a unique opportunity to play a key role in the success of Denali which is dedicated to making a difference in the lives of patients. Salary Range: $183,000.00 to $232,333.00 . Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future. Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

Keywords: , San Bruno , Director, Channel Operations, IT / Software / Systems , South San Francisco, California